|Transnet announces its new and improved
website, launched Jan/2003
of Transnet are:
1.To establish an interactive
consortium of transplantation scientists and clinicians who will
undertake the molecular modeling and validation of gene expression
signatures associated with alloantigen independent transplantation
and alloantigen dependent transplantation injury.
2.To establish an infrastructure core which will provide
the technical platform for performing gene expression profiles of
experimental and clinical transplant samples. This core will be
responsible for data acquisition and analysis. Higher order molecular
modeling will be determined in consultation with individual investigators.
3.To design and construct informatic and technical
tools to complement existing software and technical gene expression
tools for analyzing gene expression profiles associated with immune
and non immune mediated transplantation injury.
4.To establish a web-based forum for exchange of gene
expression profiling data sets. This forum will facilitate modeling
WHO IS INVOLVED IN TRANSNET?
has brought together a team of more than ten scientists from five
centers, Edmonton, Winnipeg, London, Toronto, and Montreal, throughout
Canada. These scientists have expertise in small and large animal
models of allotransplantation, transplantation injury, clinical outcomes,
genomics and gene expression profiling. These scientists are internationally
recognized leaders in the transplantation and immunology communities.
We have also established vital links with the Clinical Genomics Center
in Toronto and CanVac both of which will lend technical expertise
and allow access to proprietary reagents for analyzing immune responses.
Furthermore, the newly developed Center for Immunogenomics Research
in Toronto will contribute resources and act as the central node for
gene expression profiling.
TRANSNET EXPERIMENTAL APPROACH
||In simplest terms
Transnet will perform hypothesis driven experiments with testable
outcomes and gather tissue or clinical samples from transplant experiments
conducted in human, primate and rodent models. The Transnet core will
perform DNA microarray analysis on these samples, and analyze the
data sets using simple informatic tools to identify important identifiers
of injury, and higher order analysis to identify complex interactions
previously known and unknown.